REAC neurobiological modulation (NPO/NPPO) brings significant improvements in mobility and quality of life in fibromyalgia patients.
Introduction: The Complexity of Fibromyalgic Syndrome
Fibromyalgic syndrome (FS) is a chronic disorder characterized by widespread musculoskeletal pain, fatigue, sleep disorders, and psychopathological alterations.. Its etiopathogenesis remains under intense study, involving mechanisms such as central sensitization (CST), neurotransmitter imbalances (NIT), genetic and epigenetic factors (GEF), as well as immune system dysfunctions (DIS).
In this scenario, research is moving towards the Precision Medicine, seeking to intervene not only in peripheral symptoms, but also in changes in theEndogenous Bioelectric Activity (EBA). EBA is the common denominator influencing central nervous system function, neurotransmitter balance and epigenetic regulation.
Analysis of the Source: The Clinical Study on REAC Technology
The open-label interventional study conducted by Silva et al. REAC “Neurobiological Modulation as a Precision Medicine Treatment for Fibromyalgia” assessed the effectiveness of the technology Radio Electric Asymmetric Conveyer (REAC) in a sample of 37 patients with FS. The aim was to analyse the impact of treatments based on REAC Technology protocols on psychomotor response and quality of life.
The Therapeutic Protocol
The clinical path involved the application of two specific protocols delivered through the CE certified medical device1282 REAC BENE Mod 110 produced by ASMED® Srl of Scandicci:
- Neuro Postural Optimization (NPO): A single-session treatment aimed at improving postural control by modulating central nervous system responses.
- Neuro-Physical Optimization (NPPO): A cycle of 18 sessions aimed at optimizing neurotransmission processes and adaptive responses to environmental and exposomial stress.
Evaluation Methodology
Patients underwent standardised tests before and after surgery:
- Functional Dysmetry (FD): Semiological sign of neurobiological adaptive alterations.
- Timed Up and Go (TUG): Assessment of mobility and risk of falling.
- Sit-to-Stand (STS): Measurement of the strength and power of the lower extremities.
- Fibromyalgia Impact Questionnaire (FIQ): Multidimensional assessment of health status and functional disability.
Clinical Results and Statistical Significance
The analysis of the data showed a statistically significant improvement in all the parameters monitored..
| Evaluation test | Average Pre-Treatment | Post-Treatment Media | Value p |
|---|---|---|---|
| TUG (seconds) | 12.53 ± 2.35 | 10.37 ± 1.67 | p < 0.001 |
| STS (repeats in 30s) | 5.8 ± 1.27 | 7.5 ± 1.40 | p < 0.001 |
| FIQ Score | ~ 58 (High Impact) | ~ 28 (Low impact) | p < 0.05 |
Of particular clinical importance is the Disappearance of Functional Dysmetry in all participants immediately after the NPO session, maintaining corrective stability at the end of the NPPO cycle.
REAC Study Results
Neurobiological Modulation for Fibromyalgia (PMID: 37373891)
CONFIRMED SIGNIFICANTNESS
Methodology
Study of 37 fibromyalgia patients treated with REAC protocols NPO e NPPO. Evaluation of postural, motor and psycho-physical improvements.
Patients 37 Positive Results
Key Conclusions
- ✓ Improvement of psychomotor responses.
- ✓ Reduction of functional dysmetry.
- ✓ Reduction of global painful symptoms.
Functional dysmetry
-70%
Mean reduction in adaptive motor disorder after complete treatment.
FIQ Symptom Analysis (Baseline vs Post)
Source: Silva et al. (2023) – J. Pers. Med. Significance p < 0.05
Clinical Implications: Towards an Integrated Management
The results suggest that REAC® technology, through functional remodelling of EBA, is able to improve the dysfunctional adaptive state caused by environmental stress. For the medical professional, the integration of the NPO and NPPO protocols in the management of fibromyalgia is a state-of-the-art approach that can:
- Significantly improve the functional mobility and motor strength.
- Reduce the impact of the disease on daily activities (reduction of the FIQ score).
- Support reduction of overuse of analgesic drugs through improved central pain modulation.
Conclusions and Disclaimer
The use of non-invasive and well-tolerated neurobiological modulation treatments such as REAC NPO and NPPO is an efficient therapeutic strategy for fibromyalgia patients. The ability of REAC® Technology to intervene on adaptive and epigenetic components opens new horizons in the clinical management of this complex syndrome.
Disclaimer: The information in this article is intended for informational purposes only for healthcare professionals. The effectiveness of REAC treatments should be assessed by a specialist doctor based on the individual clinical picture of the patient. The device must be used strictly following the protocols approved by the manufacturer.
